Giant Ryan was euthanized June 14, 2012, at New Bolton Center at the University of Pennsylvania due to complications from a racing injury, including laminitis. He was 6.

The New York-bred bay colt had a white star and white socks on three legs (both front and right hind). He was foaled in 2006.

Giant Ryan fractured both sesamoids in his left foreleg during the G2 True North Handicap on June 9, 2012, at Belmont Park. He was transferred to New Bolton and scheduled for surgery to fuse the fetlock joint, but the procedure was delayed over concerns about the blood supply to the damaged area.

Unable to bear weight on the injured leg, Giant Ryan overloaded the others. After Giant Ryan developed signs of laminitis, owner Shivananda Parbhoo decided to put the horse down.

He death came five days after the injury, suffered as he battled for the lead in the stretch run of the True North.

Giant Ryan was a son of Freud out of Kheyrah (by Dayjur). He won eight races in 17 starts for earnings of $686,841.